The Rehabilitation Community Legacy Project: The Oral History of Leadership

The importance of engaging the rehabilitation profession in the collection and utilization of its oral history is illustrated through an example. A transcript from an interview with William Emener provides a first person narrative of events leading up to the first national rehabilitation counselor training conference in Crystal City, Virginia. Themes of community emerge in the telling and are used to compare and contrast to current situations in the field. The reader is invited to participate in the Rehabilitation Community Legacy Project as an act of personal leadership

Participatory Monitoring of Community-Based Rehabilitation and other Disability- Inclusive Development Programmes: the Development of a Manual and Menu

Purpose: This paper describes a three-year research project leading to the development of the CBR Monitoring Manual and Menu (MM&M). The MM&M is a practical toolkit that meets the needs of CBR managers and stakeholders, and is consistent with the philosophy of CBR and community-based disability-inclusive development. It is designed to produce meaningful and locally useful information and data, based on international data standards where possible, to enable aggregation at regional, national and international levels. Methods: Five complementary workstreams of research were carried out from 2011 to 2014: 1) literature review and analysis; 2) participatory action research with CBR stakeholders; 3) analysis and refinement of validity of concepts and structures; 4) consultation and review; and 5) synthesis of results. This article documents the method and key results of each of the five workstreams, and the lessons learned along the way. Results: The MM&M is now freely available on-line at http://sydney.edu.au/health-sciences/cdrp/projects/cbr-monitoring.shtml. Collaboration among members of the development team continues, chiefly via an on-line group to which new members have been welcomed. Conclusion and Implications: At the time of writing, the MM&M is the only international monitoring product, known to the authors, that consciously sets out to reflect both a ‘bottom- up’ and ‘top-down’ perspective of monitoring information and data. To achieve this for a complex programme such as CBR, and to align with its principles, it was essential to use a multi-component and multi-stage strategy for tool development, involving a diverse multidisciplinary team includingcollaboration with CBR stakeholders

Fifth forces, Higgs portals and broken scale invariance

© 2018 IOP Publishing Ltd and Sissa Medialab. We study the relationship between the strength of fifth forces and the origin of scale breaking in the Standard Model (SM) of particle physics. We start with a light scalar field that is conformally coupled to a toy SM matter sector through a Weyl rescaling of the metric. After appropriately normalizing the fields, the conformally coupled scalar only interacts directly with the would-be Higgs field through kinetic-mixing and Higgs-portal terms. Thus, for the first time, we describe the equivalence of conformally coupled scalar-tensor modifications of gravity and Higgs-portal theories, and we find that the usual tree-level fifth forces only emerge if there is mass mixing between the conformally coupled scalar and the Higgs field. The strength of the fifth force, mediated by the light scalar, then depends on whether the mass of the Higgs arises from an explicit symmetry-breaking term or a spontaneous mechanism of scale breaking. Solar System tests of gravity and the non-observation of fifth forces therefore have the potential to provide information about the structure of the Higgs sector and the origin of its symmetry breaking, setting an upper bound on the magnitude of any explicit scale-breaking terms. These results demonstrate the phenomenological importance (both for cosmology and high-energy physics) of considering how scalar-tensor modifications of gravity are embedded within extensions of the SM

FeynMG:a FeynRules extension for scalar-tensor theories of gravity

The ability to represent perturbative expansions of interacting quantum field theories in terms of simple diagrammatic rules has revolutionized calculations in particle physics (and elsewhere). Moreover, these rules are readily automated, a process that has catalyzed the rise of symbolic algebra packages. However, in the case of extended theories of gravity, such as scalar-tensor theories, it is necessary to precondition the Lagrangian to apply this automation or, at the very least, to take advantage of existing software pipelines. We present a Mathematica code FeynMG, which works in conjunction with the well-known package FeynRules, to do just that: FeynMG takes as inputs the FeynRules model file for a non-gravitational theory and a user-supplied gravitational Lagrangian. FeynMG provides functionality that inserts the minimal gravitational couplings of the degrees of freedom specified in the model file, determines the couplings of the additional tensor and scalar degrees of freedom (the metric and the scalar field from the gravitational sector), and preconditions the resulting Lagrangian so that it can be passed to FeynRules, either directly or by outputting an updated FeynRules model file. The Feynman rules can then be determined and output through FeynRules, using existing universal output formats and interfaces to other analysis packages

Comparison of T-cell Receptor Diversity of people with Myalgic Encephalomyelitis versus controls

Objective: Myalgic Encephalomyelitis (ME; sometimes referred to as Chronic Fatigue Syndrome) is a chronic disease without laboratory test, detailed aetiological understanding or effective therapy. Its symptoms are diverse, but it is distinguished from other fatiguing illnesses by the experience of post-exertional malaise, the worsening of symptoms even after minor physical or mental exertion. Its frequent onset after infection suggests autoimmune involvement or that it arises from abnormal T-cell activation. Results: To test this hypothesis, we sequenced the genomic loci of and T-cell receptors (TCR) from 40 human blood samples from each of four groups: severely affected people with ME; mildly or moderately affected people with ME; people diagnosed with Multiple Sclerosis, as disease controls; and, healthy controls. Seeking to automatically classify these individuals’ samples by their TCR repertoires, we applied P-SVM, a machine learning method. However, despite working well on a simulated data set, this approach did not allow statistically significant partitioning of samples into the four subgroups. Our findings do not support the hypothesis that blood samples from people with ME frequently contain altered T-cell receptor diversity

Bypass of mutagenic O 6 -Carboxymethylguanine DNA Adducts by Human Y- and B-Family Polymerases

The generation of chemical alkylating agents from nitrosation of glycine and bile acid conjugates in the gastrointestinal tract is hypothesized to initiate carcinogenesis. O6-carboxymethylguanine (O6-CMG) is a product of DNA alkylation derived from nitrosated glycine. Although the tendency of the structurally related adduct O6-methylguanine to code for the misincoporation of TTP during DNA replication is well-established, the impact of the presence of the O6-CMG adduct in a DNA template on the efficiency and fidelity of translesion DNA synthesis (TLS) by human DNA polymerases (Pols) has hitherto not been described. Herein, we characterize the ability of the four human TLS Pols η, ι, κ, and ζ and the replicative Pol δ to bypass O6-CMG in a prevalent mutational hot-spot for colon cancer. The results indicate that Pol η replicates past O6-CMG, incorporating dCMP or dAMP, whereas Pol κ incorporates dCMP only, and Pol ι incorporates primarily dTMP. Additionally, the subsequent extension step was carried out with high efficiency by TLS Pols η, κ, and ζ, while Pol ι was unable to extend from a terminal mismatch. These results provide a first basis of O6-CMG-promoted base misincorporation by Y- and B-family polymerases potentially leading to mutational signatures associated with colon cancer